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Bavaria, Eurafrasia

Four month ago I have been skocked by the medical outcome Multiple Myeloma (MM), which simply is cancer in the bone marrow all over in my esqueleto. My blood has to be dialysed three times a week now and I suffered four heavy rounds of chemical therapy, but my body does not tolerate that medical torure anymore. And so I found the new form of therapy with Cucurbitacine B against Multiple Myeloma. But our health plan does not finance Cucurbitacine B, which now is produce from cucurbit stalks in China. I have bred cucurbits for many years and know about all the different cucurbitacines, where they are lokated in parts of plants, when they are produced and how we might extract them. We can't grow that cucurbits, which Chinese use, here in European climate north of the Alps, but I have found a new of Cucurbitacine B: cotyledons of Cucurbita ficifolia in the first days out of dirt, before third leaf is developing. A few years ago I have bred Cucurbita maxima pumpkins pollinated by the Asian pumpkin or fig-leaf gourd. The outcome was very good, and I presented the hybrid here at bp in the amelio-diary, which was cancelled later. Since I did not know about my tumors at that time, my focus had been on the anti-diabetic value of these hybrid-line, but now I would like to breed many such new hybrids with various Cucurbita and Lagenaria. But my life span seems to be stongly limited by MM. Stats show an expectancy of just two years for my MM-body, and it might be very difficulty for me to grow any pumpkin, squash and gourds in 2017 season, since my gardens and patches are 90 km away from dialyses center. Because I do not want the knowledge about Cucurbitacine B from Cucurbita ficifolia and its hybrids to be lost, I offer it now to the best cucurbit-growers here at bp.

1/18/2017 10:16:19 AM

Central Illinois

was reading about Cucurbitacin just a week ago looking into cucumber beetles. Heavy infestations of adult cucumber beetles can destroy stems, cotyledons, and emerging leaves of young cucurbit plants (fig. 7). Cucurbitacins, which act as feeding stimulants, are especially elevated in the cotyledons

https://en.wikipedia.org/wiki/Cucurbitacin

1/18/2017 10:39:05 AM

Central NY

...this should be fun

1/18/2017 11:52:39 AM

Bavaria, Eurafrasia

baitmen, many cucurbitacines are poisons to scare or even to kill insects, and they normally come with the third leaf-stadium. We have to think with the natural plan in cucurbits: beetle-attractants with cucurbitacines are needed to decimate the hundreds of germinated little plants, which never could grow all together on that small spot, where the fruit is rotting. Other animals also shall eat germ buds, and so you can make a salad against you tumor with them. This anti-cancer drug is a gift of natur for us.

1/18/2017 12:44:48 PM

Bavaria, Eurafrasia

Porkchop, it is funny indeed, when you have larger cots from AG-ficifolia hybrids. We have to see, how Cucurbitacine B contents in these hybrids will be.

1/18/2017 12:51:55 PM

Little-TON - Colorado

Ludwig is that you?

1/18/2017 12:58:17 PM

Cheshire Ma USA

Here we go again LOL

1/18/2017 2:26:22 PM

Minnesota([email protected])

curcurmel,
I'm sorry to hear of your diagnosis with MM. I don't know anything about Curcurbitacine B. I will say a prayer for you.

Sincerely,
Doug Wallace

1/18/2017 2:59:55 PM

Bavaria, Eurafrasia

Wizzy, bnot was faster than you and exposed cucurmel first. Not so tricky to recognize mel for melody in both amelio and cucurmel. But I also love the work of mel Gibson, who in turn loves my work and showed one of my new pumpkin varieties named Cucurbita maxima 'Mel Gibson' on his facebook page.
DKrus, who are you? I can not remember ever having offended you, but if you wish...
Doug14, are you a member of The Clan? Anyway, I thank so much for succoring me. I thak you all so much, as you do not bear grudges here in the Wallaces' virtual amusement lounge.

1/18/2017 3:51:04 PM

Little-TON - Colorado

Time will tell Amelio, we have a great community here in our forum

1/18/2017 5:05:42 PM

Oak Grove, Mn

email on the way to you ludwig...please take the time to consider some of my input....i have spent more hours on this site that most for past few years. It has become a friendly place...like to see it stay that way. I am wondering if your son...has shown anymore interest in growing the giants?

1/18/2017 6:28:29 PM

Oak Grove, Mn

ummm...i am a fan of Doug Wallace..one of the nicest growers I have met in real life...loves orange...been involved in giant pumpkin growing way longer than most here. I think Ludwig..you need to get over your Wallace issues...in the past few years...i have come to the conclusion that you were thinking incorrectly about the 2009...and it all snowballed to a bad situation. If Ken allows it..you and the growers have a chance to forget the bad past and start fresh. Please...everyone think before you post.

ps.. Doug..i see you have started to bid on giant tomato seeds..if you don't acquire any before spring...i will certainly send you some of what I have. I think you could do well in the minnesota challenge

1/18/2017 7:32:04 PM

Bavaria, Eurafrasia

Do not (Dnot) forget the main reason of this thread here, Bob!
Will you also grow C. ficifolia aspollinators for your world class AGs. My son did not want to grow AGs for two years now, and I also did not grow giants the past two seasons, but 2017 I would like to cross AGs and giant squash with C. ficifolia, ... if health allowes it.
I do not intend to badmouth anyone or any fruit, but please Bob, do you not grow just airbag-fruits!

1/18/2017 8:12:44 PM

Oak Grove, Mn

I am sorry...Ludwig...i am not great with Latin terminology....the only latin I remember from my latin classes 35 years ago is the very first sentence i learned..."Galia est provincia" I think that your son probably was watching you and seeing how the interaction with the giant pumpkin world was affecting you...unfortunately that probably turned him away from giant growing..It is our loss. I had to push my daughter away from your email reply...she was working hard to translate your german. Stay in touch.

1/18/2017 8:51:30 PM

Minnesota([email protected])

Thanks for the offer and kind words Bob. I'll keep your generous offer in mind.

curcurmel,
If by clan, do you mean am I related to Ron and Pap? Not that I know of. It is a nice coincidence to share the same last name as these great ambassadors to this sport/hobby.

1/18/2017 9:03:49 PM

Bavaria, Eurafrasia

bnot, our son does not recognize growers, when they do it with much worse doping than Russians ever did in sport. Would you like to ban his ethics for growing fruits on vegetable? I'm far more tolerant now and accept the sportive motives of giant growers, but I can't stop politics, which will ban all that unscrupulousness in fertilization around the globe. I have watched all the seed of your 1109 record pumpkin: I would never trade the best one of them, because seed is not filled and half bleeched from diseases. I do not badmouth you, but you show us, how bad that growing for weight is to seed. Take it completely without emotions please and do not set dogs on a bear anymore!

1/19/2017 5:47:10 AM

Bavaria, Eurafrasia

Cucurbita ficifolia has five times more Cucurbitacine B in cots than C. maxima squash and pumpkins or C. moschata.
C. maxima also have various cucurbitacines in the root of the germ bud in the same amount like in cots, while C. ficifolia have only Cucurbitacine B and have that mainly in the cots. When we cross giant squash with the pollinator C ficifolia, we get hybrid-seed to germ and grow, but plants do not develop fruits with seed.

1/19/2017 6:39:25 AM

Oak Grove, Mn

Ludwig, You are showing your power of observation. Unfortunately you conclusions from the observation are not always correct. Disease is not answer to all issues. If you read further back in my diary of the 1109, you will find that the biggest issue with this plant was disease. It was exposure to a 3 in 1 herbicide including 24d. The seeds that I sent out i believe will germinate. How this exposure to the herbicide affects the genetics I do not know. In best case future generations might show an increased tolerance to herbicide. I will not be growing it this year since i am growing for big. Buta friend of mine in northern minnesota is going to try it. It is a giid thing Ludwig that you don't wish to grow the 1109.. I only have 5 seeds left.

1/19/2017 6:58:01 AM

Oak Grove, Mn

oops..biggest issue was not disease...i
i shouldnt post from my phone..always make mistakes

1/19/2017 6:59:20 AM

Central Illinois

My thought before the first post was Ludwig, but wasnt going to poke yet

1/19/2017 10:04:26 AM

Torrance, Ca.

lol wizzy!!

Winter is here.

Don't do it bob, don't do it!!

1/19/2017 12:28:10 PM

Bavaria, Eurafrasia

Bob, I have seen over fife decades such bleeched seed in gardens, where not any herbicidal influence was around.

1/19/2017 2:05:46 PM

Bavaria, Eurafrasia

Please folks return to the thread! Medical pumpkin never can be grown with all that overfertilization and herbicides used by reckless giant growers, who just do it for more weight. We need best seed and therefor must fertilize very different and far more precisely.

1/19/2017 2:20:34 PM

Oak Grove, Mn

I think you are looking at the wrong site Ludwig, This is for big pumpkins...competition growing for size. You are never going to convince the growers here to give up weight for medicinal purposes. That is not why we are here.

1/19/2017 2:38:46 PM

Bavaria, Eurafrasia

Bob, you would like to bite the bear in front of the beehive, but you just are sausage dog.

1/19/2017 5:09:43 PM

Oak Grove, Mn

i am done with this thread...i apologize to all the great friends i have on this site

1/19/2017 5:22:14 PM

Lebanon, Oregon

Bnot, your integrity is good here, nothing to apologize to your friends about.

1/19/2017 5:45:18 PM

Torrance, Ca.

there's good that came out of this Bob,,, now you know! Lol

Some things never change.

1/19/2017 5:50:44 PM

Bavaria, Eurafrasia

... the wiener dog ...

1/19/2017 5:54:49 PM

Anamosa, IA [email protected]

From Wikipedia: Cucurbitacin B[edit]

Cucurbitacin B
Cucurbitacin B from Hemsleya endecaphylla (62 mg/72 g)[6]:4 and other plants (e.g. Cucurbita andreana[7]); anti-inflammatory, any-hepatotoxic [1]:2
Cucurbitacin B 2-O-glucoside, from Begonia heracleifolia [1]:3
23,24-Dihydrocucurbitacin B from Hemsleya endecaphylla, 49 mg/72 g[6]:5
23,24-Dihydrocucurbitacin B 2-O-glucoside from roots of Picrorhiza kurrooa [1]:4
Deacetoxycucurbitacin B 2-O-glucoside from roots of Picrorhiza kurrooa [1]:5
Isocucurbitacin B, from Echinocystis fabacea [1]:6
23,24-Dihydroisocucurbitacin B 3-glucoside from Wilbrandia ebracteata [1]:7
23,24-Dihydro-3-epi-isocucurbitacin B, from Bryonia verrucosa [1]:8
Pentanorcucurbitacin B or 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-oic acid, C
25H
36O
4, white powder[5]:2

It looks like you should be looking for other types of plants, not the kind people on this site grow. I hope you find what you are looking for.

1/19/2017 5:56:16 PM

Bavaria, Eurafrasia

Thank you Iowegian, but I mentioned Hemslaya obliquely, when I wrote about CuB from China... and that we can't grow this plant in our climate. Non of the other organism would be acceptable. Just the cots from Cucurbita ficifolia are really good, and the cots of the crosses C. maxima x C. ficifolia are better than all other plants.

1/19/2017 6:10:48 PM

BC, Canada

I so missed Amelio

1/21/2017 3:40:50 AM

Bavaria, Eurafrasia

I'm flabbergastet, cavitysearch!
God help you to find the pink botton evermore!

1/21/2017 7:44:47 AM

Owensboro, Ky.

Now weather this thread is serious, or a joke, I am flummoxed? Butt the previous post is almost priceless!! To cavity search, cucurmel responds..."God help you to find the pink bottom evermore!" Rolling on the floor laughing!!! So funny!!! Especially "evermore"!!! Peace, Wayne
Now tell me this, is a pumpkin w/a pink bottom better to help w/ medicinal chemicals, or is cucurmel just making a joke?

1/22/2017 12:42:50 AM

Did a search on this stuff as medicine and as Chinese medicine .
Quite an impressive list of cancers it is being researched against because of how it works and so far looking promising.
Funny thing though the big pharma is looking into it and you know how expensive it will be then as only theirs will work!

1/22/2017 8:03:15 AM

Bavaria, Eurafrasia

Oh

1/22/2017 8:20:17 AM

Bavaria, Eurafrasia

...yes, spudder, a nephrologist also asked me, why I won't ask pharmaceutical industry first. I answered, that they can't patent C. ficifolia, and Chinese always would produce significantly more favourable - now with CuB from Hemslaya or melon handles or tomorrow with me.

1/22/2017 8:35:43 AM

Bavaria, Eurafrasia

827.5 spudder grown far below recommended NPK... you would be a good medicinal grower, I think. Please use your Gantner-cross and pollinate it with Cucurbita ficifolia.

1/22/2017 9:08:44 AM

Owensboro, Ky.

Are aMELio, and curcuMEL, the same person? Peace, Wayne

1/23/2017 12:42:20 AM

Bavaria, Eurafrasia

Congrats, Peace!

1/23/2017 2:09:46 AM

Owensboro, Ky.

cuc, ur, mel? It had been hinted at earlier in this post, I think? but now it is confirmed? Any prize? Peace, Wayne

1/24/2017 12:06:55 AM

Owensboro, Ky.

& if confirmed...and I was gone for awhile & don't think I ever met aMELio,... is the medicinal pkn stuff a bunch o crap? Sorry if it is true, just want to know? Peace, Wayne

1/24/2017 12:08:52 AM

Bavaria, Eurafrasia

Peace, think and read a little more, before you write or tipe, please.

1/24/2017 11:08:42 AM

BC, Canada

Such insouciant obsequiousness and pusillanimous puerility!

1/24/2017 12:12:58 PM

Bavaria, Eurafrasia

Today is the 114. anniversary of Otto Kahler's death. He first described my cancer the Multiple Myeloma, and therefor it also is called Morbus Kahler.
Peace, until now there is no drug to reaĺly cure Morbus Kahler. Cucurbitacin B is no miracle cure, but it might help me to live a little longer then that one or two years, common therapy can offer me.

1/24/2017 12:19:08 PM